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Abstract Bilirubin is a metabolic product of heme, and an increase in its level may be toxic to the body

doi: 10.1016/j.clnu.2016.12.027 38 MahalhalAWilliamsJMJohnsonSEllabyNDuckworthCABurkittMDet al

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This review provides a comprehensive overview of recent advances in the rational design, chemical synthesis, and biological evaluation of promising XO inhibitors for the treatment of hyperuricemia and gout